List of exclusions needed for Exchange Server
For compatibility with Microsoft Exchange, exclude the locations that Microsoft recommends. The exclusions apply to file-level scanners in the on-access scanner for ENS and Security for Microsoft Exchange. For the most accurate list of file exclusions, see the Microsoft TechNet article. Within the TechNet article, go to the 'E' section and click the article link for the version of Exchange in use in your environment. The list of Exchange articles below was updated in July 2022:

Running Windows antivirus software on Exchange servers:

• Exchange 2019
• Exchange 2016
• Exchange 2013
• Exchange 2010
• Exchange 2007

How to configure exclusions in ENS for Exchange Server
When you configure exclusions, always apply the principle that the more precise the exclusion, the smaller the potential security risk. For instructions to configure exclusions, see the "Preventing Threat Prevention from blocking trusted programs, networks, and services" section of the Endpoint Security Threat Prevention Product Guide

Exclusions needed if Security for Microsoft Exchange is installed
The following extra exclusions are needed only if Security for Microsoft Exchange is installed:

• <installation folder> (Default installation folder is C:\Program Files (x86)\McAfee\MSME)
• <defined quarantine folder>\MSMEData (Default defined quarantine folder is %programdata%\McAfee\MSME\Data)
• The following Security for Microsoft Exchange processes:
  • RPCServ.exe
  • SAFeService.exe
  • postgres.exe
  • MaseRulesUpdater.exe